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Updated: Aug 3, 2026

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
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Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin

Published on: January 17, 2012

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在突变的GRN和Grn缺陷的外围髓状细胞中,ASO介导的GPNMB的淘汰破坏了 lysosomal 功能和免疫反应

Rebecca L Wallings, Drew A Gillett, Hannah A Staley

    bioRxiv : the preprint server for biology
    |August 30, 2024
    PubMed
    概括

    糖蛋白非转移性黑色素瘤蛋白B (GPNMB) 在progranulin缺乏症中的上调可能是补偿性的. 在FTD-GRN中准GPNMB可能会破坏免疫细胞功能,这表明它.

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