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Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
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工程总编辑器具有最小的基因组错误

Vikash P Chauhan, Phillip A Sharp, Robert Langer

    bioRxiv : the preprint server for biology
    |August 30, 2024
    PubMed
    概括

    新的主要编辑器 (PE) 通过重新定位DNA断裂几乎可以消除基因组编辑错误. 这一策略显著减少了不必要的插入和删除 (indels),提高了基因编辑技术的精度.

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