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Updated: Jun 14, 2025

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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
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在具有认知障碍的西班牙裔个体中,肠道和口腔微生物组的不同模式
bioRxiv : the preprint server for biology
|August 30, 2024
概括
阿尔茨海默病与口腔微生物组的变化有关,像Dialister这样的特定细菌在认知障碍患者中增加. 肠道微生物组的改变也与健康标志物相关,但没有发现协同效应.
科学领域:
- 微生物组研究的研究.
- 神经退行性疾病研究研究神经退行性疾病研究
- 口腔健康和全身性疾病
背景情况:
- 阿尔茨海默病和相关的痴呆症 (ADRD) 与肠道微生物组失调有关.
- 口腔微生物组在ADRD中的作用及其与肠道微生物组的相互作用尚未研究.
- 在认知障碍 (CI) 中,调查口腔和肠道微生物组模式至关重要.
研究的目的:
- 评估与没有认知障碍 (CI) 的西班牙裔个体口腔和肠道微生物组的不同模式.
- 在ADRD中探索口腔和肠道微生物之间潜在的协同效应.
- 为了将微生物组成与临床测量如葡萄糖和胆固醇相关联.
主要方法:
- 来自32名参与者的便和唾液样本的16S rRNA基因测序 (17 CI, 15 NC).
- MaAslin2用于临床数据和微生物含量之间的相关性分析.
- 差异丰度和多样性分析,以比较CI和NC组.
主要成果:
- 在CI和NC组之间没有葡萄糖或胆固醇的显著差异,但肠道微生物组与这些标志物相关.
- 在CI参与者中增加了口服属 (Dialister,Fretibacterium,Mycoplasma) 的丰富性.
- 在CI参与者中,抗炎性肠道属 (Shuttleworthia,Holdemania,Subdoligranulum) 的丰度降低.
- 在口腔和肠道微生物之间没有检测到协同效应.
结论:
- 口腔微生物组显示与认知衰退相关的显著修改,类似于肠道微生物组.
- 与牙周病相关的特定口腔细菌在CI患者中更为普遍.
- 需要对更大的队列进行进一步的研究,以证实这些发现,并了解ADRD中口腔肠道微生物群的相互作用.
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