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可注射的多糖水凝作为局部化氧化输送配方

Evan S Feura¹, Sara E Maloney¹, Ivie L Conlon¹

¹Department of Chemistry, University of North Carolina at Chapel Hill CB 3290, Chapel Hill, NC 27599.

Advanced materials technologies

|August 30, 2024

概括

由氧化德克斯和改性纤维素或氨酸制成的可注射的多糖水凝提供了多方面的生物医学应用. 这些新型的氧化释放水凝具有可调节的特性和良好的生物相容性.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
药物输送系统药物输送系统

背景情况:

可注射的水凝对局部治疗提供有希望.
基于多糖的水凝提供生物相容性和可调节性质.
氧化 (NO) 输送具有各种生物医学应用的潜力.

研究的目的:

为了合成和表征可注射的多糖液体,用于输送氧化.
评估这些水凝的质性,降解性和释放性.
评估开发的水凝系统的体外细胞毒性.

主要方法:

使用氧化德克斯和改性碳素甲基纤维素或氨酸制备水凝.
风湿学测试以确定存储模块和机械性能.
在不同pH值的体外降解研究和NO释放动力学的评估.
使用多个细胞系进行细胞毒性评估.

主要成果:

基于碳甲基纤维素的水凝与基于氨酸的水凝相比,显示出更高的储存模块.
氨酸水凝显示出明显更高的胀比率.
加入NO捐赠体减少了水凝模块,并影响了NO释放动力学.
在较低的pH值下,水凝降解得更快,NO加速降解.
大多数水凝提取物没有表现出细胞毒性,除了针对人类牙纤维细胞的氨酸.

结论:

可注射的多糖水凝可以根据特定的生物医学需求量身定制.
这些水凝具有可调节的机械性能,可控制的降解和NO释放能力.
开发的水凝为生物医学应用中局部氧化物输送提供了一个多功能且在很大程度上无毒的平台.

关键词:

碳氧甲基纤维素的碳氧甲基纤维素.德克斯兰 (Dextran) 是一种氨酸是什么? 氨酸是什么?可以注射的水凝.氧化氧化的使用方法聚糖是一种多糖.

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