Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Primary aldosteronism-induced hypokalemic rhabdomyolysis syndrome: a case report and literature review.

Frontiers in medicine·2026

Same author

The evolution of ultrasound in sarcopenia assessment: Global trends, technological shifts, and clinical frontiers.

Journal of back and musculoskeletal rehabilitation·2026

Same author

Basilic vein transposition to enhance arteriovenous fistula venous outflow: a single-center technical note.

BMC surgery·2026

Same author

Cross-View Multimodal Vision-Based Assessment Framework for Traditional Chinese Medicine Rehabilitation Training.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026

Same author

Incidence and risk factors of post-transplant diabetes mellitus after kidney transplantation: a systematic review and meta-analysis.

Frontiers in endocrinology·2026

Same author

The landscape of MET alterations in non-small cell lung cancer in Southeastern China: a real-world study.

BMC cancer·2026

Search research articles

相关实验视频

Updated: Jun 15, 2026

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

Published on: October 24, 2011

机器学习优化酶/ZIF生物复合材料,提高封装效率和生物活性.

Weibin Liang¹, Sisi Zheng¹, Ying Shu¹

¹School of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, NSW 2008, Australia.

|August 30, 2024

概括

此摘要是机器生成的。

我们开发了一种机器学习 (ML) 辅助的策略,以优化酶/地质伊米达酸框架 (ZIF) 合成. 这种方法显著提高了酶的性能,加速了各种应用的生物催化剂的开发.

更多相关视频

Extraction of Plant-based Capsules for Microencapsulation Applications

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

Preparation of Functional Silica Using a Bioinspired Method

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

相关实验视频

Last Updated: Jun 15, 2026

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

Published on: October 24, 2011

Extraction of Plant-based Capsules for Microencapsulation Applications

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

Preparation of Functional Silica Using a Bioinspired Method

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

科学领域:

生物化学和材料科学材料科学
酶不移动化酶不移动化
纳米技术纳米技术

背景情况:

在热性伊米达酸框架 (ZIFs) 中的酶固定对于生物催化非常重要.
优化合成以提高酶性能 (封装效率,保留活性,热稳定性) 仍然是一个挑战.
机器学习 (ML) 为复杂的优化问题提供了强大的工具.

研究的目的:

介绍第一个ML辅助设计策略,以优化酶/ZIF合成.
在ZIF中增强葡萄糖氧化酶 (GOx) 和胡卜过氧化酶 (HRP) 的性能.
建立一个工作流程,以加快酶/ZIF系统的开发.

主要方法:

使用了一种代的ML驱动的培训-设计-合成-测量工作流.
采用葡萄糖氧化酶 (GOx) 和胡卜过氧化酶 (HRP) 作为模型酶.
选择Zn(eIM) 2 (eIM = 2-乙烯胺酸盐) 作为优化模型ZIF.

主要成果:

发现了优化的GOx/ZIF (G151) 和HRP/ZIF (H150) 配方.
取得的整体绩效指数 (OPI) 值至少比基线研究高1.3倍.
使用随机森林模型确定了合成参数,结构和酶性能之间的关键关系.

结论:

机器学习辅助的设计策略有效地加速了酶/ZIF合成的优化.
这种方法为未来的酶固定化研究提供了宝贵的见解.
该战略对生物催化剂,药物输送和传感应用具有重大前景.