血液动力学反应对活跃站的哪些组成部分预测心血管疾病和死亡率? 来自爱尔兰长度老龄化研究的数据
medRxiv : the preprint server for health sciences
|August 30, 2024
概括
在站立时分析心率和血压反应,揭示了与心血管疾病和死亡率的明显联系. 这些集成的血液动力学标志物为神经心血管健康提供了洞察力.
科学领域:
- 心脏病学 心脏病学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 站立时的综合血液动力学反应 (主动站立 - AS) 可能表明神经心血管功能.
- 在AS期间的心率 (HR) 和血压 (BP) 反应与心血管疾病 (CVD) 和死亡率单独相关.
- 整个HR/BP响应曲线之间的长度关联在AS,事件CVD和死亡率期间被评估了12年.
研究的目的:
- 评估AS和事件心血管疾病和死亡率期间完整HR/BP响应曲线之间的纵向关联.
- 调查AS期间整合整个血液动力学反应曲线是否为心血管疾病和死亡风险提供了新的见解.
- 确定AS作为神经心血管健康的潜在整合性标志物.
主要方法:
- 在AS期间,在4336名个体 (61.5±8.2年) 中进行了节奏对节奏动态HR/BP测量.
- 功能主要组件分析 (FPCA) 应用于HR/BP响应曲线.
- 在FPCA衍生的HR/BP曲线组件与12年内发生的心血管疾病和死亡率之间的关联分析.
主要成果:
- 在AS期间,高于AS前的缩血压 (SBP) 和减弱的SBP恢复与所有原因死亡率的增加有关 (HR: 1.14).
- 较高的基线/峰值HR和较低的30后HR与较低的循环死亡率相关 (HR:0.78).
- 整个AS中HR升高与其他原因死亡率更高相关 (HR: 1.48).
结论:
- 在AS期间的HR/BP反应和12年心血管疾病发病率和死亡率之间存在明显的关系.
- 在AS期间整合全血动力学响应曲线提供了对心血管风险的更细致的理解.
- 在中年和老年人中,AS血动力学反应可能成为神经心血管健康的有价值的整合性标记.
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