术前暴露于细颗粒物质和术后并发症风险:一个单中心观察队列贝叶斯分析
medRxiv : the preprint server for health sciences
|August 30, 2024
概括
在手术前暴露于细颗粒物空气污染 (PM2.5) 增加了术后并发症. 这突出了空气污染作为潜在的外科手术前期风险因素,影响手术结果.
科学领域:
- 环境健康 环境健康
- 手术结果研究研究.
- 流行病学 流行病学
背景情况:
- 细颗粒物空气污染 (PM2.5) 与不利的健康影响有关.
- 术后PM2.5暴露对美国成年人的术后结果的影响还未得到充分研究.
- PM2.5可能会引起炎症,与手术压力相互作用,增加并发症.
研究的目的:
- 调查术前PM2.5暴露和术后并发症之间的关联.
- 确定手术前一周PM2.5度升高是否会增加重大术后并发症的风险.
主要方法:
- 一个单一的学术医疗中心的49,615名选择性外科病人的回顾性队列研究 (2016-2018).
- 患者地址被地理编码,并与每日人口普查轨道PM2.5估计水平联系起来.
- 根据人口统计,季节,邻里处于不利地位和并发症进行调整的等级贝叶斯回归.
主要成果:
- 术后并发症以剂量依赖的方式增加,随着更高的PM2.5暴露.
- 每增加10ug/m3的最大单日PM2.5暴露 (手术前7天) 后,并发症的几率增加8%.
- 增加30倍的PM2.5 (1至30ug/m3) 增加了27%以上的并发症概率;在混杂物控制后,这种关联仍然存在.
结论:
- 在手术前增加的PM2.5暴露与剂量依赖的术后并发症增加有关.
- 空气污染可能是重要的外科手术期间风险因素,影响手术结果.
- 需要对更大的数据集进行进一步的研究,以确定有风险的人群并了解污染物相互作用.
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