在帕金森病中,手术前的认知特征预测了脑下深层刺激后的认知衰退
Josef Mana1, Ondrej Bezdicek1, Filip Růžička1
1Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Charles University, Prague, Czech Republic.
The European journal of neuroscience
|August 30, 2024
概括
帕金森病 (PD) 患者的认知衰退在脑下深层脑部刺激 (STN DBS) 后是平均轻微的,但差异很大. 手术前的执行功能缺陷预测更快的下降.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 认知能力下降是帕金森病 (PD) 的一个显著的非运动症状.
- 脑下深层大脑刺激 (STN DBS) 可能会受到认知衰退的影响,影响治疗结果.
- 了解手术后的认知变化对于管理接受STN DBS的PD患者至关重要.
研究的目的:
- 在PD患者中,在STN DBS后的认知衰退的特征.
- 确定与加速后STN DBS认知衰退相关的手术前认知概况.
- 为分析PD研究中的认知变化和测量误差提供一个模型.
主要方法:
- 对126名接受STN DBS治疗的PD患者进行了回顾性观察研究.
- 平均随访时间为3.54年,重复进行认知评估.
- 使用综合性术前神经心理测试,探索性因子分析和贝叶斯概括线性混合模型进行分析.
主要成果:
- 在马蒂斯痴呆症评分尺度上观察到年平均0.90点的轻度认知下降.
- 认知衰退的高个体间变异性被注意到,尽管真正的得分变化低于可靠的截止值.
- 手术前执行职能缺陷是术后认知衰退率的唯一可靠预测因素.
结论:
- 接受STN DBS治疗的PD患者经历了轻微的,逐渐的年平均认知衰退,具有显著的个体变异性.
- 术前对执行功能的评估可以可靠地确定患有长期认知衰退风险较高的PD患者.
- 开发的模型可以帮助在未来的STN DBS研究中区分真正的认知变化和测量错误.
更多相关视频
07:14A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
Published on: May 31, 2016
14.7K
07:26Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
Published on: September 26, 2019
7.8K
相关概念视频
01:15Parkinson's Disease: Overview
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
01:24Parkinson Disease l: Introduction
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...