一种基于粉和自热纸的分析装置 (SH-PAD) 用于检测双A
Shekhar Panicker1,2, Anusha Prabhu1, Balachandar Sundarrajan1
1Microfluidics, Sensors and Diagnostics (μSenD) Laboratory, Centre for Microfluidics, Biomarkers, Photoceutics and Sensors (μBioPS), Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Analytical methods : advancing methods and applications
|August 30, 2024
概括
本研究介绍了低成本的纸质设备,用于检测有害环境污染物双A (BPA). 这些创新方法可以在水中快速地在现场检测BPA,从而在资源有限的环境中帮助公共卫生.
科学领域:
- 分析化学 分析化学
- 环境科学 环境科学
- 材料科学 材料科学 材料科学
背景情况:
- 双甲 (BPA) 是一种广泛存在的环境污染物,已知有毒性,内分泌干扰,致癌性和致变性作用.
- 暴露于BPA是通过食物,水,尘埃和皮肤接触而发生的,因此需要可靠的检测方法.
- 现有的BPA检测方法往往不足以进行快速的现场分析,这凸显了对可访问技术的需求.
研究的目的:
- 为快速检测双A (BPA) 开发具有成本效益的全合一纸质分析设备.
- 创建用户友好的诊断工具,适合于点的护理应用程序,特别是在资源有限的环境.
主要方法:
- 在纸上制造疏水屏障,使用粉石精确定义通道.
- 开发一种基于纸的自我加热分析装置 (SH-PAD),利用外热反应进行高效的色度BPA检测.
- 使用的Folin-Ciocalteu试剂和碳酸用于BPA在加水样本中的量化.
主要成果:
- 实现了1.64毫米±0.05毫米的水友通道分辨率,使用粉壁,有效地限制水溶剂.
- 仅需0.017美元的SH-PAD可以保持5分钟以上的充足热量,从而能够快速测定色度BPA.
- 两种开发的方法都成功地检测到BPA降至2μg mL-1的水样.
结论:
- 开发的基于纸张的分析设备为BPA检测提供了用户友好和成本效益的解决方案.
- 这些方法对照料点诊断和环境监测具有前景,特别是在缺乏先进实验室设施的地区.
- 随时可用的材料的创新性使用有助于快速制造必要的诊断工具.
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