胎儿回声性肠可能与肠道微生物群有关:一项前性队列研究
1Department of Medical Imaging, Quanzhou Medical College, Quanzhou, China.
Journal of clinical ultrasound : JCU
|August 30, 2024
概括
胎儿回声性肠道 (EB) 可能与肠道微生物群的改变有关. 研究表明,细菌丰富度存在差异,这表明微生物群组成和EB发展之间存在潜在的关系.
科学领域:
- 微生物组研究的研究.
- 胎儿的发育 胎儿的发育
- 胃肠道的健康状况
背景情况:
- 胎儿回声性肠道 (EB) 是第二个三个月的超声检查中常见的发现.
- 孤立EB的病因在很大程度上是未知的.
- 研究胎儿肠道微生物组提供了一个新的视角.
研究的目的:
- 为了比较出生后健康胎儿和第二个月内生殖性肠道的胎儿之间的肠道微生物组合.
- 探索胎儿回声性肠道和正在发育的肠道微生物群之间的关系.
主要方法:
- 16S rRNA测序对来自三个组的样进行了测序:健康胎儿 (对照组),患有回声肠道 (EB) 的胎儿,以及患有回声肠道和其他异常 (C-EB) 的胎儿.
- 分析包括多样性指数和属级丰度.
- 测序优化产生了超过120万个高质量的序列.
主要成果:
- 两组之间没有观察到阿尔法多样性 (香农,辛普森指数) 的显著差异.
- 与对照组相比,EB和C-EB组中的大肠杆菌/Shigella的丰度明显较低.
- 像Staphylococcus,Methylobactrium和Curvibacter这样的特定属在EB组中显示出更高的丰度.
结论:
- 胎儿回声性肠道可能与改变的肠道微生物群组成有关.
- 这些发现表明肠道微生物群在肠道回声性肠道病变发生过程中可能发挥作用.
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