严重的先天膜心脏病的性别相关差异:ESC-EORP膜心脏病II调查
Julia Mascherbauer1, Andreas Kammerlander2, Christian Nitsche2
1Department of Internal Medicine 3, University Hospital St. Pölten, Dunantplatz 1, 3100 St. Poelten, Karl Landsteiner University of Health Sciences, Krems, Austria.
膜心脏病 (VHD) 的性别差异表明女性年龄较大,患病更严重. 推治疗一致性较低的女性与额头肌狭窄和额头肌吐,虽然生存率相似.
科学领域:
- 心脏病学 心脏病学
- 临床研究 临床研究
- 医学中的性别差异.
背景情况:
- 在VHD II EURObservational研究计划中,收集了有关患有严重原生膜心脏病 (VHD) 的患者的数据.
- 了解VHD特征和治疗的基于性别的变异对于有效的患者管理至关重要.
研究的目的:
- 调查严重本源VHD.患者疾病表现和治疗模式的性别差异.
- 评估干预措施与基于性别的既定指南的一致性.
主要方法:
- 分析了来自欧洲和北非208个中心的5219名患者,持续6个月.
- VHD亚型的分类包括大动脉狭窄 (AS),大动脉吐 (AR),额头狭窄 (MS),额头吐 (MR) 和右侧VHD.
- 基于2012年ESC和2014年AHA/ACC VHD指南的治疗一致性评估.
主要成果:
- 与男性相比,女性年龄较大,症状较强,并具有较高的EuroSCORE II.
- 双主动脉和AR在男性中更为常见;在老年女性中, mitra 疾病,三回 (TR) 和AS更为常见.
- 在患有多发性硬化和原发性复发性脊髓炎的妇女中,与推治疗的一致性较低. 拒绝干预的原因因性别而异.
- 妇女的TR患病率较高,但同时发生的三干预率相似. 住院和6个月生存期显示没有性别差异.
结论:
- 膜心脏病亚型在两性之间表现出不同的模式.
- 关节狭窄和初级关节反的妇女与指南推的干预措施的一致性较低.
- 尽管疾病特征和治疗坚持程度有差异,但男性和女性的6个月生存率相似.
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