通过使用高分辨率异视镜检测状细胞癌的早期发现
Muhammad Hyder Junejo1,2, Oluwatobiloba Ifeoluwa Oyebanji3, Baihan Wang4
1Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
Clinical and experimental dermatology
|August 30, 2024
概括
英国一家专业中心的高分辨率无光镜 (HRA) 与全国平均水平相比,显著增加了早期门状细胞癌 (aSCC) 的检测. 这表明HRA可以改善早期诊断,并有可能减少这种高危人群的治疗发病率和死亡率.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 在英国,部平细胞癌 (aSCC) 往往是晚期诊断的,只有12%在第1阶段被检测出来.
- 内皮质瘤 (AIN) 是aSCC的前体,专业服务管理这些情况.
- 高分辨率异视镜 (HRA) 是专业的异位瘤服务中的一个关键的诊断工具.
研究的目的:
- 评估HRA在英国专业中心的aSCC早期检测中的附加值.
- 将在专科单位诊断的aSCC的阶段分布与国家数据进行比较.
主要方法:
- 从2016年1月到2021年6月,在霍默顿生殖器瘤服务 (HANS) 中对初级aSCC诊断的横截面分析.
- 审查患者记录,组织病理学和放射学报告,以使用TNM分类 (AJCC版本8) 确定aSCC阶段.
- 将HANS数据与英国国家统计局的aSCC国家统计数据进行比较.
主要成果:
- 在HANS,53例aSCC诊断中有66%是第一阶段,明显高于全国平均水平的12% (P < 0.001).
- 在HANS没有诊断出4期aSCC,与国家数据形成鲜明对比.
- 在HANS中检测到的早期 (第一阶段) aSCC的比例在统计学上显著高于英国国家队列.
结论:
- 在高风险队列中使用HRA进行监测和检查可能会导致aSCC的早期检测.
- 通过HRA对aSCC的早期检测可以促进不那么病态的治疗选择.
- 在专门中心实施HRA计划可能有助于降低癌的死亡率.
相关概念视频
Assessment of the Rectum and Anus
173
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
173
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
63
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
63


