在新喀里多尼亚岛上大规模的HEV基因型3爆发
Florence Abravanel1,2, Clémence Vignon3, Ambroise Mercier4
1Toulouse University Hospital, Hôpital Purpan, Place du Dr Baylac, Laboratoire de Virologie, National Reference Centre for Hepatitis E, Toulouse, France.
Hepatology (Baltimore, Md.)
|August 30, 2024
概括
肝炎E病毒 (HEV) 基因型3在新喀里多尼亚爆发,导致住院和死亡. 调查发现了一种新的HEV-3亚型,与亚洲和非洲的流行病菌株不同.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在2023年8月至12月期间,在新喀里多尼亚报告了症状性肝炎E病毒 (HEV) 感染.
- 这促使紧急开展流行病学和病毒学调查,以确定感染的来源.
研究的目的:
- 为了确定新喀里多尼亚的HEV感染源.
- 为了描述涉及疫情的HEV菌株.
主要方法:
- 在患者,食品和养猪场中检测HEV RNA.
- HEV菌株的测序和表征.
- 在无症状的献血者中进行血清流行研究.
主要成果:
- 报告了127例症状病例,22.8%需要住院治疗,病例死亡率为2.3%.
- 所有测序的菌株都是HEV基因型3,显示出一种新的HEV-3亚型.
- 献血者的HEV IgG血清流行率从2020年的9.2%增加到2024年的17.3%.
结论:
- 新喀里多尼亚疫情与HEV基因型3有关,与其他地方的HEV-1/2相关流行病不同.
- 显著比例的症状病例需要住院治疗,突出了这一HEV-3疫情的严重性.
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