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孕期糖尿病女性的供应和甲状腺功能:一个队列研究
Hana Vítková1, Kateřina Anderlová1,2, Jan Krátký1
1Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Endocrine connections
|August 30, 2024
概括
与健康对照组相比,妊娠期糖尿病 (GDM) 的孕妇的摄入量较低,缺乏率更高. 在GDM中补充可以减少产周并发症.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 孕妇的水平在怀孕期间至关重要,它会影响孕妇和新生儿的甲状腺功能.
- 孕期糖尿病 (GDM) 可能会影响饮食习惯,从而影响摄入量.
- 尿液中度 (UIC) 和新生儿甲状腺刺激激素 (TSH) 是状态的关键指标.
研究的目的:
- 为了比较患有GDM的孕妇的供应与健康的孕妇.
- 在GDM中评估状态与母亲/新生儿甲状腺功能之间的关系.
- 评估摄入量对患有GDM的妇女产周并发症的影响.
主要方法:
- 对195名患有GDM和88名对照女性的尿度 (UIC) 和血清甲状腺功能测试 (TSH,FT4,TPOAb) 的分析.
- 在154名新生儿的子组 (115名GDM,39名对照组) 中测量新生儿TSH.
- 组之间的状态,甲状腺功能和围产期并发症率的比较.
主要成果:
- 与对照组 (150.05μg/L) 相比,患有GDM的女性的UIC中位数 (89.50μg/L) 显著降低,这表明缺乏症更高.
- 在88.7%的GDM病例和50%的对照群中观察到缺乏;最佳摄入量仅在4.6%的GDM和37.5%的对照群中.
- 低胆固醇血在GDM (12.3%) 与对照组 (3.4%) 之间更为普遍,新生儿TSH>5.0mIU/L在5.2%的GDM新生儿中被观察到.
- 患有GDM和低甲状腺素血症的女性早产率较高;FT4与HbA1c负相关.
- 在GDM中补充与显著较低的围产期并发症率 (7.69%与28.85%相比) 有关.
结论:
- 与健康怀孕相比,患有GDM的怀孕与缺乏症的患病率更高有关.
- 在GDM中,孕产妇的低甲状腺血与早产相关,与FT4和HbA1c负相关.
- 在患有GDM的妇女中,补充剂似乎可以降低产周并发症的风险.
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