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Updated: Jun 14, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
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基因组语言模型是所有你需要的吗? 探索对蛋白质下游任务的基因组语言模型

Sam Boshar1, Evan Trop1, Bernardo P de Almeida2

  • 1InstaDeep, Cambridge, MA 02142, United States.

Bioinformatics (Oxford, England)
|August 30, 2024
PubMed
概括

基因组语言模型 (gLMs) 可以预测蛋白质功能,在某些任务上匹配或超过蛋白质组模型. 一个联合模型和3mer代币化进一步提高了性能,统一了基因组学和蛋白质组学.

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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