早期精神病的静态和动态失联:与症状尺寸的关系
Giulia Cattarinussi1,2, David Antonio Grimaldi1, Mohammad Hadi Aarabi1,2,3
1Department of Neuroscience (DNS), University of Padova, Padua, Italy.
Schizophrenia bulletin
|August 30, 2024
概括
早期精神病与大脑连接的显著变化有关,影响静态和动态功能网络. 这些变化与患者的认知缺陷和积极症状相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 改变功能连接 (FC) 是精神病中常见的发现.
- 在早期精神病 (EP) 中研究时间变化的FC为神经机制提供了洞察力,避免了药物或疾病持续时间的混.
研究的目的:
- 研究早期精神病 (EP) 患者的静态和动态功能连接 (FC).
- 在EP中探索FC测量和临床/认知变量之间的大脑-行为关联.
主要方法:
- 使用了休息状态功能磁共振成像 (rs-fMRI).
- 分析了96名PE患者和56名健康对照 (HC).
- 空间组独立组分分析计算了静态和动态FC (dFNC);部分相关性评估了大脑行为联系.
主要成果:
- 与HC相比,EP个体表现出改变的静态FC,在条纹体,状体,额头和状皮层的连接性更高,在额头,状体和状皮层的连接性更低.
- 在EP的认知功能与右条纹体FC负相关.
- 在EP中,所有dFNC参数都发生了变化,正症状与元状态变化和总距离负相关.
结论:
- 精神病,即使在早期阶段,也涉及到固有的静态和动态FC的复杂变化.
- 这些连接性变化可能是精神病中观察到的积极症状和认知缺陷的基础.
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