时间限制饮食对癌症的临床影响:系统性审查
Eleah J Stringer1,2,3, Rob W G Cloke1,4, Lindsay Van der Meer1,2,3
1Nursing and Allied Health Research and KT Department, BC Cancer, Vancouver, BC V5Z 1G1, Canada.
Nutrition reviews
|August 30, 2024
概括
时间限制饮食 (TRE) 对癌症患者来说是可行的,并可能为瘤学提供好处. 这种饮食干预有望改善生活质量,并可能减少癌症标志物.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 代谢健康 代谢健康
背景情况:
- 全球癌症负担日益增加,需要探索饮食干预措施.
- 临床前研究表明,时间限制饮食 (TRE) 影响新陈代谢和肠道微生物群,可能抑制癌症发生.
- 癌症中TRE的人类研究正在出现,需要对当前证据进行综合.
研究的目的:
- 系统地评估TRE在癌症患者的临床和代谢效应.
- 为了比较TRE与自由自在的饮食或替代饮食模式.
- 综合人类研究中关于TRE治疗癌症的证据.
主要方法:
- 在多个数据库 (MEDLINE,Embase,CINAHL,Cochrane,Web of Science,SCOPUS) 进行全面的文献搜索,截至2023年1月.
- 包括原始的研究设计,协议和临床试验注册表,重点关注间歇性禁食和癌症.
- 从24个选定的条目中提取,比较和批判性分析数据 (8篇文章,2篇摘要,1篇协议,13个注册表).
主要成果:
- 在癌症患者中观察到TRE的高坚持率 (67-98%).
- 在多项研究中报告的生活质量的改善.
- 初步证据表明,TRE可以减少癌症标志物 (例如CEA),降低复发率,并在8周内改善代谢风险因素 (BMI,脂肪,葡萄糖调节,炎症).
结论:
- 时间限制饮食 (TRE) 是癌症患者可行的和可接受的饮食干预措施.
- 初步发现表明,与TRE相关的潜在瘤益处.
- TRE证明对癌症患者的生活质量产生积极影响.
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