在eosinophilic慢性鼻炎中肠道微生物组的改变
Yibo Liang1, Chenting Zhang1,2, Xin Xiong1
1Department of Otorhinolaryngology Head and Neck Surgery, Institute of Otolaryngology of Tianjin, Key Laboratory of Auditory Speech and Balance Medicine, Key Medical Discipline of Tianjin (Otolaryngology), Tianjin First Central Hospital, Quality Control Centre of Otolaryngology, Tianjin, 300192, China.
概括
肠道微生物组的变化存在于患有带鼻息肉的eosinophilic慢性鼻炎 (eCRSwNP) 的患者中. 这些变化与疾病严重程度相关,为这种局部亚托皮性疾病提供了新的见解.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 肠道微生物群显著影响着亚托皮性疾病的发展.
- 带有鼻的eosinophilic慢性鼻炎 (eCRSwNP) 是一种局部化的亚托皮性疾病,具有系统性免疫影响.
- 在CcRSwNP患者的肠道微生物组变化尚未得到充分了解.
研究的目的:
- 为了研究eCRSwNP患者的肠道微生物组合.
- 为了比较eCRSwNP患者,非eCRSwNP患者和健康对照之间的肠道微生物群.
- 确定肠道微生物组变化与eCRSwNP疾病严重程度之间的相关性.
主要方法:
- 一项横截面研究利用了16S rRNA基因测序.
- 肠道微生物群DNA测序在17名CRSwNP患者,9名非CRSwNP患者和13名健康对照进行.
- 生物信息学方法用于组间比较.
主要成果:
- 与健康对照组相比,eCRSwNP患者表现出不同的肠道微生物组成.
- 两组之间没有观察到肠道微生物群α多样性的显著差异.
- 与疾病严重程度相关的微生物组成差异,包括隆德 - 麦凯CT得分和组织异osinophil百分比.
- 便细菌和Turicibacter的丰度与疾病严重程度标志物有积极的相关性.
结论:
- 在CcRSwNP患者中发现了肠道微生物组的变化.
- 这些肠道微生物组的变化与eCRSwNP的严重程度有关.
- 研究结果表明,肠道失调和eCRSwNP的病理生理学之间存在联系.
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