牙周炎与心脏代谢和静血参数的关联
Hester Groenewegen1, Jaime F Borjas-Howard2, Karina Meijer2
1Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen, P.O. Box 30.001, Groningen, 9700 RB, The Netherlands. h.groenewegen@umcg.nl.
Clinical oral investigations
|August 30, 2024
概括
牙周炎的严重程度与更高的威尔布兰德因子 (VWF) 水平有关,但全口腔提取并没有改善这些标记物. 在对照组中,严重的牙周炎并没有显著改变血静或炎症系统.
科学领域:
- 牙周病学 牙周病学
- 心血管医学 心血管医学
- 血液学 血液学 血液学
背景情况:
- 牙周炎是一种普遍的炎症性疾病.
- 它与心脏代谢和血液静止参数的关联需要进一步研究,特别是关于非心脏代谢疾病人群的治疗效应.
研究的目的:
- 调查牙周炎严重程度与心脏代谢和静血参数之间的关联.
- 评估全口提取对这些参数的影响.
主要方法:
- 一项综合的横截面和纵向研究,涉及54名牙周炎患者接受全口拔牙和50名对照患者.
- 牙周炎的严重程度通过牙周炎表面积 (PISA) 进行评估.
- 血液静止 (VIII因子,·威尔布兰德因子[VWF],内源性血栓潜力,d-二次体,凝块溶解时间) 和心血管风险 (C-反应蛋白[CRP],脂质谱) 参数在提取前和后测量.
主要成果:
- 与对照组相比,患有牙周炎的个体的平均VWF和CRP水平较高,高密度脂蛋白水平较低.
- VWF与PISA有显著的相关性,表明VWF增加,牙周炎的严重程度更高.
- 在全口提取后,在个体中没有观察到测量参数的显著变化.
结论:
- VWF水平与牙周炎的严重程度有关.
- 全口抽取似乎没有改善VWF水平.
- 在对照组中,严重的牙周炎并没有导致其血液静止或炎症系统发生实质性变化.
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