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帕金森病的认知功能:与基底腺中周血管空间的关联

Zhenglong Luo^1,2, Yangfan Zhu^1,2, Yongyun Zhu^1,2

¹Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, P.R. China.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|August 30, 2024

概括

基底中的扩大周周血管空间 (EPVS),而不是白质超强度 (WMH),与帕金森病 (PD-MCI) 中的轻度认知障碍有关. 对EPVS的MRI检测可能有助于早期诊断PD患者的认知衰退.

科学领域:

神经学神经学
放射学放射学是一门学科.
神经成像是一种神经成像.

背景情况:

认知障碍是帕金森病 (PD) 的常见症状之一.
轻度认知障碍 (MCI) 在PD (PD-MCI) 中意味着向痴呆症过渡.
早期发现PD-MCI对于患者的护理和治疗至关重要.

研究的目的:

评估MRI上的扩大周血管空间 (EPVS) 和白质超强度 (WMH) 是否可以作为PD-MCI的生物标志物.
研究EPVS,WMH和帕金森病患者的认知衰退之间的关联.

主要方法:

从200名PD患者 (2021年4月至2022年4月) 的头骨MRI扫描进行了回顾性分析.
患者分为PD没有认知障碍 (PD-NCI) 或PD轻度认知障碍 (PD-MCI) 的PD.
后勤回归模型 (单变量和多变量) 用于分析MRI发现,临床人口统计因素和认知状态之间的关联.

主要成果:

单变量分析显示,基本质中严重的EPVS,严重的WMH,年龄较大,发病晚,男性性别低,教育程度低,疾病持续时间较长,甘油三水平低,尿酸低,微型精神状态检查得分低作为PD-MCI的风险因素.
多变量回归,经过临床人口统计因素的调整后,确定了低教育水平和基底中的EPVS作为认知障碍的独立风险因素.

结论:

在基底中严重的EPVS和较低的教育程度是PD-MCI的独立预测因素.
在本研究中,没有发现WMH是PD-MCI的独立风险因素.
基底的非侵入性MRI检测EPVS显示了作为帕金森病认知能力下降的早期指标的潜力.

关键词:

大脑白质的强度过高.认知认知是一种认知.教育水平教育水平帕金森病是帕金森氏症的一种疾病.周血管空间是周血管空间.

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