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在青少年异常性关节炎中疾病损伤
Ruksana Sidhique1, Narendra Kumar Bagri2, Manisha Jana3
1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
几乎一半患有青少年异常性关节炎 (JIA) 的儿童经历了关节损伤. 类风湿因子 (RF) 和抗CCP阳性增加了儿童JIA患者这种损伤的风险.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 临床免疫学临床免疫学
- 肌肉骨健康 肌肉骨健康
背景情况:
- 青少年异常性关节炎 (JIA) 是一种慢性自身免疫性疾病,影响儿童.
- 与疾病相关的损害是JIA的一个重大问题,特别是在资源有限的环境中.
- 了解损害的流行和预测因素对于有效管理至关重要.
研究的目的:
- 确定患有JIA的儿童中与疾病相关的关节和关节外损伤的患病率.
- 确定与儿科JIA患者疾病相关损伤相关的预测因子.
- 在资源有限的背景下评估损害.
主要方法:
- 一项单中心研究招募了105名儿童 (≤18岁) 患有JIA,根据ILAR标准诊断,疾病持续时间>1年.
- 关节和关节外损伤使用少年关节炎损伤指数 (JADI) 和修改的JADI分数进行评估.
- 使用cJADAS和CHAQ分数评估的疾病活动和残疾.
主要成果:
- 48.6%的患有JIA的儿童患有关节损伤,21.9%患有关节外损伤.
- 患有风湿性因子 (RF) 和/或抗循环酸 (CCP) 阳性儿童的关节损伤几率明显更高 (OR:4.4).
- 一半患有肠炎相关关节炎 (ERA) 的儿童经历了关节损伤;四名儿童因脑膜炎而受到眼睛损伤.
结论:
- 有关关节炎的儿童中很大一部分患有关节损伤和关节外损伤.
- 射频和/或抗CCP阳性是儿科JIA关节损伤增加的关键预测因素.
- 这些发现凸显了在资源有限的环境中早期发现和干预的必要性.
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