基于多层网络的自闭症谱系障碍的动态网络重新配置灵活性的性别差异
Le Gao1,2, Yabo Cao1,2, Yigeng Zhang3
1School of Information Science and Engineering, Yanshan University, Qinhuangdao, 066004, China.
Brain imaging and behavior
|August 30, 2024
概括
自闭症谱系障碍 (ASD) 显示了大脑网络灵活性中的性别差异. 患有自闭症的女性在关键网络中的灵活性较低,这预测了症状严重程度,与患有自闭症的男性不同.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 精神病学是一个精神病学.
背景情况:
- 在自闭症谱系障碍 (ASD) 中,动态网络重新配置发生了变化.
- 以前的自闭症研究主要使用男性样本,网络动态中的性别差异不清楚.
- 了解性别差异至关重要,因为ASD在男性中的患病率更高.
研究的目的:
- 研究自闭症谱系障碍 (ASD) 中动态网络重新配置的性别差异.
- 探索ASD的男性和女性之间大脑网络灵活性如何不同,以及典型的发展对照.
- 确定网络灵活性是否以性别特定的方式预测症状严重程度.
主要方法:
- 利用自闭症脑成像数据交换 (ABIDE) 数据库中的静止状态功能磁共振成像 (fMRI) 数据.
- 采用多层网络分析来评估动态网络重新配置的灵活性.
- 进行了双向差异分析 (ANOVA),以检查诊断的性别相互作用效应.
主要成果:
- 在皮带-骨管网络 (CON),中央执行网络 (CEN),突出网络 (SN) 和皮质下网络 (SUB) 中发现了显著的诊断性相互作用.
- 与典型发育 (TC) 的女性相比,ASD的女性在CON,CEN,SN和SUB中表现出较低的网络灵活性.
- 患有自闭症的男性在CEN和SUB方面表现出比患有自闭症的女性更高的灵活性,而CON,CEN,SN和SUB方面的灵活性仅在患有自闭症的女性中预测症状严重程度.
结论:
- 在自闭症患者的动态网络重新配置灵活性方面存在显著的性别差异.
- 在自闭症中,网络灵活性在不同性别之间不均,并且与特定的大脑区域有关.
- 研究结果强调,在未来的自闭症研究和潜在的治疗策略中,必须将性视为关键因素.
更多相关视频
09:13Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
Published on: April 22, 2015
16.5K
11:14A Novel Experimental and Analytical Approach to the Multimodal Neural Decoding of Intent During Social Interaction in Freely-behaving Human Infants
Published on: October 4, 2015
10.9K
相关概念视频
01:19Autism Spectrum Disorder
77
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
77
01:26Modeling in Therapy
59
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
59
02:12Relationship Formation
39.9K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
39.9K