氧化和心血管事件在患有系统性狼的患者
Lamiae Grimaldi1,2,3, Tom Duchemin4, Yann Hamon4
1Department of Pharmacology, Hospital Group Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Paris, France.
JAMA network open
|August 30, 2024
概括
目前在全身性红斑狼 (SLE) 患者中使用氧化与心血管事件的风险降低有关,包括心肌梗塞和中风. 持续治疗是这种保护作用的关键.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 系统性红斑狼 (SLE) 显著增加了早期心血管 (CV) 事件的风险.
- 据推测,氧化可以减轻SLE患者的心血管风险因素,但它对动脉事件的直接保护作用需要确认.
研究的目的:
- 调查氧化使用与SLE患者心肌梗塞 (MI),中风和其他血栓栓塞事件 (OTEs) 的风险之间的关联.
主要方法:
- 在2010-2020年期间,使用法国国家医疗保健数据库 (SNDS) 进行了一项嵌套病例控制研究.
- 该研究包括52883名SLE患者的队列,其中病例经历了CV事件,对照对各种因素进行了匹配.
- 氧化暴露被分为当前,远程或不存在,并使用多变量条件后勤回归分析.
主要成果:
- 当前使用氧化与复合心血管事件的几率明显降低 (OR,0.63;95% CI,0.57-0.69).
- 与没有近期暴露相比,观察到MI (OR,0.72),中风 (OR,0.69) 和OTE (OR,0.58) 的几率的具体降低.
- 远程使用氧化没有显示出与心血管结局减少的显著关联.
结论:
- 目前的氧化使用表明,在患有SLE的患者中,抗心血管事件具有保护性关联.
- 这些发现强调了持续的氧化治疗对于减轻该人群中心血管风险的重要性.
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