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在主观认知衰退的背前的融合多模式成像异常

Xuan-Yu Li^1,2, Li-Xia Yuan^3,4,5, Chang-Chang Ding⁶

¹Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.

Journal of Alzheimer's disease : JAD

|August 30, 2024

概括

神经成像显示了主观认知衰退 (SCD) 个体的背部前肌的一致异常. 这些发现将粉样β沉积和改变的大脑功能与早期阿尔茨海默病的认知变化联系起来.

科学领域:

神经成像是一种神经成像.
阿尔茨海默氏症疾病研究研究
认知神经科学认知神经科学

背景情况:

主观认知衰退 (SCD) 在神经成像模式中显示出各种异常.
在多种成像技术中,在SCD中没有发现一致的局部异常.

研究的目的:

在SCD中研究化β (Aβ) 沉积,葡萄糖代谢和静止状态功能性MRI (RS-fMRI) 度量中的合局部变化.
为了确定与SCD相关的特定大脑区域和功能变化.

主要方法:

五十名SCD患者和15名正常对照 (NC) 接受了[18F]-florbetapir PET,[18F]-fluorodeoxyglucose PET,并同时进行RS-fMRI.
进行了Aβ沉积,葡萄糖代谢,低频波动幅度 (ALFF),区域均性 (ReHo) 和中心度 (DC) 的voxel智能分析.

主要成果:

SCD患者在左背前 (dPCu) 中表现出Aβ沉积和葡萄糖代谢的增加.
在SCD患者的左dPCu中观察到ALFF,ReHo和DC的降低.
dPCu显示了与默认模式网络的连接性改变以及Aβ沉积的梯度.

结论:

在SCD中,背部前部的融合神经成像变化存在.
这些dPCu的变化可能与情节性记忆以外的认知功能有关,例如注意力.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.功能性磁共振成像技术功能性磁共振成像技术定子发射断层扫描 (PET).预先预测的情况主观认知衰退主观认知衰退

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