年轻期痴呆症与先前存在的外周静脉疾病的关联
Shih-Han Hung1,2,3, Alison H Chang4, Yen-Fu Cheng5,6,7,8
1Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan.
Journal of Alzheimer's disease : JAD
|August 30, 2024
概括
在年轻发病的痴呆症患者中,外围前庭障碍明显更常见. 这表明前体功能障碍可能会导致早期痴呆症的发展.
科学领域:
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 流行病学 流行病学
背景情况:
- 年轻发病痴呆症和外围前体障碍之间的联系尚不清楚.
- 以前的观察表明,在老年人群中存在关联.
研究的目的:
- 为了调查年轻发病痴呆症和先前存在的外周前置障碍之间的关联.
- 利用2010年台湾纵向健康保险数据库来获取基于人口的数据.
主要方法:
- 采用了一种病例控制研究设计.
- 包括989名年轻发病痴呆症患者和2967名倾向性得分匹配的对照.
- 多重物流回归模型评估了相关性,并对各种共变量进行了调整.
主要成果:
- 患有年轻发病痴呆症的患者患有外围前庭障碍的患病率显著更高 (18.3%与8.2%相比).
- 特定的疾病,如Meniere病,BPPV和前庭神经炎也更为频繁.
- 之前的外周前置障碍使年轻发病痴呆的几率增加了2.6倍.
结论:
- 在年轻发病的痴呆症和先前存在的外围前庭障碍之间存在显著的关联.
- 静脉管功能障碍可能是导致幼年痴呆症发病的因素.
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