扩大的周血管空间与高脉冲波速度独立相关:一个横截面研究
Yoshino Kinjo1,2, Naoki Saji2, Kenta Murotani3,4
1Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus Graduate School of Medicine, Nishihara-cho, Okinawa, Japan.
Journal of Alzheimer's disease : JAD
|August 30, 2024
概括
高臂脚脉冲波速率 (PWV) 与基底质中大周血管空间有关,可能会使老年人认知障碍恶化.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 老年学是一门学科.
背景情况:
- 大脑小血管疾病 (SVD) 和认知障碍与脉冲波速度 (PWV) 有关.
- 腕PWV与SVD标志物扩大周血管空间 (EPVS) 之间的关联尚未得到充分证实.
研究的目的:
- 在没有痴呆症的个体中调查脚骨PWV与EPVS严重程度之间的关系.
- 探索这种关系对认知功能的潜在调解.
主要方法:
- 74名参与者的横截面研究,评估认知功能,臂PWV和大脑MRI.
- 在基底 (BG-EPVS) 和半骨中心 (CSO-EPVS) 量化了EPVS.
- 使用多变量逻辑回归和因果调解分析.
主要成果:
- 高臂脚PWV和年龄独立地与增加的BG-EPVS严重程度有关.
- 年龄,但不是手腕脚PWV,与CSO-EPVS严重程度有关.
- 腕PWV对通过BG-EPVS调解的轻度认知障碍 (MCI) 有显著的间接影响.
结论:
- 臂PWV与基底腺扩大周血管空间 (BG-EPVS) 的严重程度有关.
- 升高的PWV可能会通过增加脑血管脉动性来导致认知衰退,从而加剧BG-EPVS.
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