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在波动和非波动的环境中,可视化的遗传系统的演变

Rocío Fernández-Fernández¹, David R Olivenza², Esther Weyer^3,4

¹Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Sevilla, Sevilla 41012, Spain.

Proceedings of the National Academy of Sciences of the United States of America

|August 30, 2024

概括

细菌表观遗传开关,就像沙门氏菌中的opvAB操作子一样,通过可逆转换表型来帮助种群适应不断变化的环境. 这种投注对冲策略增强了在波动条件下生存,支持进化适应.

科学领域:

微生物学微生物学
进化生物学进化生物学
遗传学是一个遗传学.

背景情况:

表观遗传机制使细菌的表型转换成为可能,这对于在动态环境中适应至关重要.
数学模型表明表观遗传开关是适应性的,但实验验证是有限的.
在不可预测的条件下,表型异质性可能是一个进化优势.

研究的目的:

实验性研究opvAB操作子表观遗传开关在沙门氏菌的适应中的作用.
为了确定OpvAB bistability是否在波动的环境中提供了生存优势.
为表观遗传适应的理论模型提供经验支持.

主要方法:

使用了Salmonella enterica及其opvAB操作子,该操作子控制表观遗传切换.
在变化和稳定的环境条件下进行细菌进化实验.
采用计算模拟来建模表观遗传变异及其适应值.

主要成果:

证明了OpvAB双稳定性 (OpvAB^OFF/敏感和OpvAB^ON/抗) 在不断变化的环境中保持,但不是稳定的环境.
展示了OpvAB表观遗传开关的可逆性.
观察到,转换所赋予的现象型异质性作为投注对冲策略.

结论:

以opvAB操作子为例的表观遗传变异是避免在波动的环境中发生突变的关键进化策略.
在沙门氏菌中的OpvAB切换预先通过投注对冲使种群适应菌体遭遇.
实验发现支持游戏理论模型在不可预测的环境中表型异质性的好处.

关键词:

适应性战略适应性策略细菌实验进化的细菌实验进化表观遗传开关是一个表观遗传开关.波动的环境,波动的环境.菌-细菌相互作用

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