月经生殖因素与骨关节炎风险的因果关系:单变量和多变量孟德尔随机化研究
Xinzhe Tan1, Yifang Mei2, Yihao Zhou1
1College of Acu-moxibustion and Massage, Heilongjiang University Of Chinese Medicine, Haerbin, Heilongjiang Province, China.
PloS one
|August 30, 2024
概括
第一次活产的早期年龄增加了整体关节炎 (OOA) 和膝关节关节炎 (KOA) 的风险. 其他生殖因素,如最后一次活产的年龄和第一次性交的年龄,也与KOA风险有关.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 生殖健康 生殖健康
背景情况:
- 观察性研究表明月经生殖因子 (MRF) 和骨关节炎 (OA) 之间存在联系.
- 目前尚不清楚MRF和OA之间的确切因果关系.
- 门德尔随机化 (MR) 可以帮助阐明这些因果关系.
研究的目的:
- 调查各种MRF和OA之间的因果关系.
- 评估特定生殖因素对整体,膝关节和部OA的影响.
- 为了调整潜在的混因素,如BMI.
主要方法:
- 利用了全基因组关联研究 (GWAS) 的总结统计数据.
- 进行了单变量和多变量门德尔随机化 (MR) 分析.
- 采用逆方差加权 (IVW) 作为主要方法,以MR Egger和加权中位数作为补充.
- 进行了敏感性分析,以测试异质性和水平性.
主要成果:
- 第一次新生儿 (AFB) 的年龄较低与整体OA (OOA) 和膝盖OA (KOA) 的风险增加有关.
- 最后活产的年龄 (ALB) 和第一次性交的年龄 (AFSI) 与KOA负相关.
- 更年期的早期年龄 (AMP) 与部OA (HOA) 的风险增加有关.
- 较早开始服用口服避孕药 (ASOC) 的年龄与OOA和KOA有关.
- 初潮时的年龄 (AAM) 和活产数 (NLB) 对OA的影响在BMI调整后是微不足道的.
结论:
- 第一次活产的早期年龄是OOA的风险因素.
- 早期的AFB,ALB和AFSI被确定为KOA的危险因素.
- 生殖因素,特别是与分娩相关的因素,显著影响KOA风险.
- 这些发现为促进最佳年龄生育和加强围产期护理提供了指导.
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