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用针对生殖线的SOSIP剪切剂进行免疫接种,在婴儿中引起广泛中和抗体前体

Ashley N Nelson1, Xiaoying Shen2, Sravani Vekatayogi2

  • 1Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.

Science immunology
|August 30, 2024
PubMed
概括

早期儿童用特定HIV包裹SOSIP (GT1.1) 免疫接种显示,在性行为开始前开发广泛中和抗体 (bnAbs) 是有前途的,这对于有效的HIV疫苗至关重要.

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相关概念视频

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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