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从基于机制的保持糖酶抑制剂到基于活动的糖酶分析

Marta Artola1, Johannes M F G Aerts1, Gijsbert A van der Marel1

  • 1Leiden Institute of Chemistry, Leiden University, 2300 RA, Leiden, The Netherlands.

Journal of the American Chemical Society
|August 30, 2024
PubMed
概括

基于活动的蛋白质分析 (ABPP) 使用基于环醇的新型探针来识别和研究保留糖酶 (GH). 这些工具促进了对人类健康,疾病和微生物过程的理解.

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Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
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