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从18F-FDG PET/CT研究的不同协议的患者中剂量估计和优化策略的分析

Pooja Dwivedi^1,2, Ashish Kumar Jha^2,3, Sneha Mithun^2,3

¹Department of Nuclear Medicine and Molecular Imaging, Advanced Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, India.

Radiation protection dosimetry

|August 30, 2024

概括

这项研究评估了来自18F-2--2-脱氧-D-葡萄糖正子发射断层扫描/计算机断层扫描 (PET/CT) 的辐射剂量. 计算机断层扫描 (CT) 在大多数全身方案中比PET贡献的辐射剂量更多,突出了需要优化的领域.

科学领域:

医疗成像医学成像
辐射剂量计辐射剂量计
核医学是一种核医学.

背景情况:

阳位子发射断层扫描/计算机断层扫描 (PET/CT) 对于诊断和分期恶性瘤至关重要.
准确的辐射剂量评估对于患者的安全和优化成像方案至关重要.

研究的目的:

评估和比较来自不同18F-2--2-脱氧-D-葡萄糖 (FDG) PET/CT协议的有效辐射剂量.
为了确定哪个组件 (PET或CT) 对总辐射剂量有更大的贡献.

主要方法:

对207名确诊恶性瘤患者进行PET/CT后期分析.
使用注射活性和ICRP 128指南估计的PET有效剂量 (E).
使用剂量长度产物 (DLP) 和ICRP 102转换因子估计的CT有效剂量.

主要成果:

在各种PET/CT协议中观察到有效剂量 (E) 的显著差异 (P < .001).
全身PET/CT的平均PET剂量为4.9 ± 0.9 mSv,平均CT剂量为10.1 ± 1.2 mSv.
在所有方案中,CT剂量超过PET剂量,除了脑PET/CT;总平均E为17.0±1.7mSv.

结论:

辐射剂量在不同的PET/CT成像协议之间有显著差异.
计算机断层扫描 (CT) 是大多数全身PET/CT手术中总辐射剂量的主要贡献者.
定期监测和优化策略是有效管理辐射暴露的必要条件.

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