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用光显微镜和数字形态测量用于预测结局的本土脏活检中组织病理性慢性性得分的验证

Nandhini Gangadaran¹, Debasis Gochhait¹, Dhanajayan Govindan²

¹Department of Pathology, JIPMER, Puducherry 605006, India.

Annals of diagnostic pathology

|August 30, 2024

概括

评估脏活检慢性得分方法,包括整片成像,可以改善预后. 将组织病理学评分与衰竭风险方程 (KFRE) 结合起来,可以提高对病进展的预测准确性.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
病理学病理学病理学
数字病理学数字病理学

背景情况:

对脏活检慢性病的定量评估有助于预后,但缺乏标准化.
慢性病 (CKD) 的定性评估提供了宝贵的见解,但复制性挑战仍然存在.

研究的目的:

使用光显微镜和整片成像,比较两个慢性评分系统 (方法1和方法2) 的预后效用和可重现性.
评估结构测量的预后价值,如非硬化质密度和面积/体积等.
评估慢性性得分方法与衰竭风险方程 (KFRE) 的联合预测能力.

主要方法:

对101名患有本地细胞活检的患者进行了回顾性纵向研究.
在光显微镜和整个幻灯片成像下应用两个半定量慢性度评分方法.
结构测量的形态测量分析和与KFRE集成用于预测分析.

主要成果:

这两种慢性度评分方法都显著预测了估计的球过率 (eGFR) 降低和需要脏替代疗法.
与KFRE结合的第1方法显示,与第2方法相比,脏存活率预测优越.
方法2显示了更高的观察者间可重现性;联合KFRE和组织病理学显示了增强的预测准确性.

结论:

整体幻灯片成像提高了活检慢性得分的精度.
形态测量测量提供了与后续EGFR相关的补充预后信息.
将病学评分与KFRE结合起来,可以更好地预测病结果.

关键词:

慢性功能衰竭慢性功能衰竭淋巴细胞突炎是什么?脏活检 - 脏活检

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