神经免疫系统对过敏原的识别
Isaac M Chiu1, Caroline L Sokol2
1Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Current opinion in immunology
|August 30, 2024
概括
神经系统和免疫系统相互作用,驱动2型免疫反应. 感官神经元检测过敏原,促进过敏炎症和相关的全身反应.
科学领域:
- 神经免疫学 神经免疫学
- 第二类免疫力
背景情况:
- 神经系统和免疫系统复杂地调节生理过程.
- 2型免疫反应对过敏性疾病和对寄生虫的宿主防御至关重要.
研究的目的:
- 阐明感官神经元在启动和调节2型免疫反应中的作用.
- 了解过敏免疫中神经元和免疫细胞之间的双向通信.
主要方法:
- 研究了感官神经元与免疫细胞的相互作用.
- 研究了神经元信号传递对树突细胞和巨细胞的影响.
- 评估了2型细胞因子对神经元功能的影响.
主要成果:
- 感官神经元通过检测过敏原来启动先天性和适应性2型免疫.
- 神经元通过抑制1型免疫反应来促进2型炎症.
- 2型细胞因子增强神经元的激活,创造一个积极的反循环.
结论:
- 神经免疫相互作用对于编排2型免疫反应至关重要.
- 这一神经免疫轴有助于过敏性炎症,厌恶,过敏反应和多敏感性.
相关概念视频
Allergic Reactions
27.3K
Overview
27.3K
Cross-reactivity
31.0K
Overview
31.0K
Antigens Involved in Adaptive Immunity
476
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
476
Hypersensitivities
559
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
559
Antibody Structure
59.6K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
59.6K
Special Features of Adaptive Immunity
779
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
779


