索马里裔美国人的多发性硬化症:自然或培养?
Nabeela Nathoo1, Nur Neyal2, Elizabeth J Atkinson3
1Department of Neurology, Mayo Clinic, Rochester, MN, USA; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.
Multiple sclerosis and related disorders
|August 30, 2024
概括
索马里裔美国人 (SA) 患有多发性硬化症 (MS) 的人表现出与白人美国人 (WA) 相似的疾病过程,并且比同一地区的非洲裔美国人 (AA) 有更好的疾病过程.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 过程在不同种族和种族的人口中存在显著差异.
- 明尼苏达州的索马里移民人口提供了一个独特的机会,可以在本土非洲人中研究MS.
- 了解这些差异对于个性化MS护理至关重要.
研究的目的:
- 为了比较临床特征和疾病修饰疗法 (DMT) 在索马里美国人 (SA),非裔美国人 (AA) 和白人美国人 (WA) 患有MS (pwMS) 的患者中的使用.
- 在这些不同群体中调查MS进展和治疗的潜在差异.
主要方法:
- 在一个单一的中心 (梅奥诊所) 进行了一项回顾性队列研究,其中包括在罗切斯特250英里以内居住的PwMS,MN.
- 收集的数据包括移民时的年龄,MS发病时的年龄,DMT使用和类型,MS阶段,进展性MS (PMS) 发病时的年龄和严重MS (EDSS ≥6).
主要成果:
- 与非洲裔美国人 (AApwMS) 和白人美国人 (WApwMS) 相比,索马里裔美国人 (SApwMS) 在MS发病时更年轻.
- SApwMS比AApwMS和WApwMS更早地接受DMT治疗,但接受纳塔利祖马布或抗CD20疗法的频率较低.
- 渐进性多发性硬化症 (PMS) 的发生频率在各组中相似,但SApwMS的PMS发病年龄比AApwMS更大.
结论:
- 最近移民的索马里裔美国人pwMS表现出类似于WApwMS的疾病过程.
- 在SApwMS中,MS病程似乎比同一个地理区域的AApwMS更有利.
- 这些发现强调了在MS管理中考虑种族和移民因素的重要性.
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