疲劳影响与身体和神经行为因素之间的关联:在进展性多发性硬化症患者中进行的一项探索
L Connolly1, S Chatfield1, J Freeman1
1Faculty of Health, School of Health Professions, University of Plymouth, Devon, UK.
Multiple sclerosis and related disorders
|August 30, 2024
概括
渐进性多发性硬化症 (MS) 的疲劳与行走困难以及焦虑和抑郁等神经行为因素密切相关. 管理策略应解决身体和心理健康方面的问题,以改善pwPMS的结果.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 临床心理学 临床心理学
背景情况:
- 疲劳是多发性硬化症 (MS) 的普遍和衰弱症状,显著影响生活质量.
- 了解疲劳,身体功能和神经行为因素之间的相互作用对于有效的管理至关重要,特别是在渐进性MS (pwPMS) 中.
- 有限的研究已经明确研究了这些关系在认知障碍的个人pwPMS.
研究的目的:
- 调查自我报告的疲劳与各种身体和神经行为指标之间的关联,在一个大型的国际队列中,有pwPMS的认知障碍个体.
- 确定导致这一特定人群疲劳的关键因素.
- 为了告知临床实践和未来的研究方向,以管理pwPMS疲劳.
主要方法:
- 一项涉及308名pwPMS患者的横截面研究,来自CogEx试验.
- 使用修改疲劳影响量表 (MFIS) 评估疲劳.
- 测量身体功能 (有氧能力,体力活动,行走表现,行走困难) 和神经行为因素 (焦虑,抑郁,疾病影响).
- 使用统计分析,包括t测试,奇方,皮尔森相关性,部分相关性和多变量逻辑回归.
主要成果:
- 67.2%的pwPMS参与者报告显著疲劳 (MFIS总数≥38).
- 疲劳的个体表现出较差的行走表现 (6MWT),更糟糕的自我报告的行走困难 (MSWS-12),以及较低的中度至强烈的体力活动 (MVPA).
- 在疲劳和神经行为测量 (焦虑,抑郁) 和疾病影响之间观察到强烈的相关性,而与大多数身体测量的关联较弱,除了走路困难 (MSWS-12).
- 增加行走困难 (MSWS-12) 独立地与经历疲劳的更高可能性有关.
结论:
- 患有进展性多发性硬化症的认知障碍个体的疲劳与身体 (特别是行走困难) 和神经行为因素显著相关.
- 在pwPMS中有效地管理疲劳需要采取全面的方法,以解决身体限制和心理健康问题.
- 进一步的研究应侧重于针对渐进性MS疲劳的这些多方面的综合干预措施.
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