在日本对IL23R的多态性,吸烟和性结肠炎的病例控制研究rs76418789
Yoshihiro Miyake1, Keiko Tanaka1, Chisato Nagata2
1Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Ehime, Japan.
Cytokine
|August 30, 2024
概括
介素-23受体 (IL23R) 单核酸多态 rs76418789 与日本性结肠炎 (UC) 风险降低有关. 吸烟与这种遗传因素相互作用,影响具有IL23R A等位基因的个体的UC发育.
科学领域:
- 遗传学 是一个遗传学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 介素-23 (IL-23) 在性结肠炎 (UC) 发病过程中起作用.
- 在之前的一项全基因组研究中,在亚洲人群中发现了IL23R p.G149R (rs76418789) 和UC之间的关联.
- 这项研究的重点是验证日本人口中的这种关联.
研究的目的:
- 在日本队列中调查IL23R SNP rs76418789和性结肠炎 (UC) 之间的关联.
- 探索rs76418789与环境因素 (如吸烟) 在UC发展中的潜在相互作用.
主要方法:
- 采用了一种病例控制研究设计.
- 该研究包括384例UC病例和661名对照受试者.
- 根据性别,年龄和吸烟情况进行了统计调整.
主要成果:
- 在UC病例中没有rs76418789的AA基因型,但在对照中存在0.5%.
- rs76418789的GA或AA基因型的携带者表现出显著降低UC风险 (OR=0.67).
- 在rs76418789和吸烟史 (p=0.03) 之间发现了显著的相互作用,吸烟只会增加UC风险,至少有一个A等位基因的个体.
结论:
- 一个IL23R单核酸多态 rs76418789显著与日本人口的性结肠炎有关.
- 这项研究突出了rs76418789和吸烟在UC病因学的背景下之间的一种新的相互作用.
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