生物活性多和功能性多糖的潜在干预和相互作用,以缓解炎症性肠病 - - 综述
Muhammad Salman Farid1, Bakhtawar Shafique2, Rui Xu3
1College of Food Science and Engineering, Ningbo University, Ningbo 315800, China.
聚醇和多糖因子通过减少炎症和改善肠道健康,对治疗炎症性肠道疾病 (IBD) 有希望. 封装增强了它们的传递和有效性,但需要更多的人体试验.
科学领域:
- 胃肠道学和免疫学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 炎症性肠病 (IBD) 是一种复杂的疾病,受各种因素的影响,包括饮食,微生物和遗传学.
- 多和多糖因其在治疗IBD方面的治疗潜力而得到认可.
- 诸如结肠中多的低稳定性和生物可用性等挑战阻碍了IBD治疗.
研究的目的:
- 审查多和多糖在IBD管理中的生物效应.
- 探索它们的抗氧化,抗炎和微生物组调节特性.
- 突出基于多糖的封装作为克服多提供挑战的策略.
主要方法:
- 文献综述侧重于体外和体内研究.
- 对多-多糖相互作用 (共价,非共价,简单,复杂封装) 的分析.
- 在IBD的临床前模型中评估治疗结果.
主要成果:
- 多和多糖体显示出抗氧化,抗炎和微生物组调节作用,对IBD有益.
- 聚糖封装改善了多的稳定性,生物可用性和向性输送.
- 药物管理减少了IBD相关的损伤,增加了有益的微生物,并促进了短链脂肪酸的产生.
结论:
- 聚醇和多糖,特别是当被封装在多糖中时,为IBD提供了一个有前途的治疗策略.
- 这些化合物可以减轻IBD症状,调节肠道微生物群,并具有抗癌性质.
- 进一步的人类临床试验至关重要,以验证它们在治疗炎症性肠病中的有效性.
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