玛-protocadherins调节树的自我识别和动态,以驱动自我回避.
Samantha Ing-Esteves1, Julie L Lefebvre1
1Program for Neuroscience and Mental Health, Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
Current biology : CB
|August 30, 2024
概括
集群的原始干蛋白 (cPcdhs) 调节哺乳动物神经元中的状体自我避开. 这项研究表明,玛-Pcdhs在兄弟树突之间调解自我识别和收回,确保适当的神经元形态.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
背景情况:
- 神经元在细胞表面的分子影响下形成特定的形状,这些分子控制着树突的生长.
- 树突的自我避开确保了神经元区域内的统一分支分布.
- 集群原核素 (cPcdhs) 参与了哺乳动物调节状物自我避开的过程.
研究的目的:
- 直接调查在发育过程中树体自我避开的动态和机制.
- 定义马-Pcdhs (Pcdhgs) 在自我/非自我识别和星爆亚马克林细胞 (SACs) 中树状树叶图案中的作用.
主要方法:
- 实时成像和四维 (4D) 量化小鼠视网膜SACs中的树形态发生.
- 追踪树突突突出动态,包括自我接触和非自我接触事件.
- 分析PCdhg缺乏的SAC,以评估对自我规避机制的影响.
主要成果:
- 自接触的树突突突出比非自接触的具有更长的寿命,其中一些形成循环.
- 缺少Pcdhgs显著减少了自我接触的突起的收缩,导致树突桥梁和捆绑.
- 在PCdhg缺乏的SAC中,非自我接触的突起动力学没有受到影响.
结论:
- 玛-Pcdhs (Pcdhgs) 积极调解接触兄弟树突之间的自我识别和收回.
- 由Pcdhgs调节的自我避开,对于塑造哺乳动物神经元中的随机树突外生和强大的模式形成至关重要.
相关概念视频
Cadherins in Tissue Organization
3.0K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.0K
Structure of Cadherins
3.3K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
3.3K
Catenins
2.3K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
2.3K
Assembly of Signaling Complexes
5.7K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
5.7K
Pinching-off of Coated Vesicles
3.1K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
3.1K
GPCR Desensitization
5.9K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
5.9K


