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基于聚卡普罗拉克的形状记忆泡作为自适配的阴道支架

Ashley J Hicks¹, Courteney Roberts², Andrew Robinson¹

¹Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, United States.

Acta biomaterialia

|August 30, 2024

概括

一种由形状记忆聚合物泡制成的新型自贴性阴道支架可以在盆腔治疗后预防阴道狭窄. 这种创新的支架可以压缩插入,并扩展以适应患者,改善生活质量.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
妇科器械妇科器械

背景情况:

阴道狭窄是骨盆辐射治疗和重建性手术后的一个使人虚弱的并发症.
对于阴道狭窄的现有治疗方法往往是侵入性的,缺乏以患者为中心的设计.
迫切需要有效的,患者友好的解决方案来预防阴道狭窄.

研究的目的:

开发和评估使用形状记忆聚合物 (SMP) 泡的自适合性阴道支架.
设计一种能够进行压缩插入和随后扩张的支架,以符合个体患者的解剖学.
为了解决预防阴道狭窄的临床需要,在盆腔后进行治疗.

主要方法:

使用可光愈聚烯酸 (PCL) 宏体 (明星PCL-四烯酸和线性PCL-二烯酸) 制造高孔度SMP泡.
研究泡结构和宏类型,以优化在生理温度下的形状固定性和形状恢复.
开发一个定制的模具和固化系统用于支架制造,然后在长椅骨盆模型上进行缩和部署测试.

主要成果:

在37°C时,Star-PCL-tetraacrylate泡表现出降低的化温度,并显示出显著的形状恢复 (∼84%) .
制造的支架在缩状态下显示出极好的形状固定性 (>95%) 和近乎完整的形状恢复 (∼100%).
在模拟的骨盆模型中,SMP阴道支架在5分钟内迅速扩张,并在生理压力下保持阴道口径,降低10%以下.

结论:

形状记忆聚合物泡为开发自适配的阴道支架提供了一个有前途的平台,以防止狭窄.
开发的支架设计和开源工具促进了妇科设备的代设计.
这种以患者为导向的方法有可能显著改善接受盆腔治疗的患者的治疗结果和生活质量.

关键词:

乳液模板设计乳液模板设计形状记忆的聚合物.阴道狭窄阴道狭窄

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