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对多种重金属和金属的同时暴露会诱导抗氧化,炎症,DNA损伤和视通路的剂量依赖调节,进而导致小鼠的功能障碍

Damini Singh1, Priyanka Bist1, Sangeeta Choudhary1

  • 1Department of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan 304022, India.

Environmental toxicology and pharmacology
|August 30, 2024
PubMed
概括

环境中的重金属混合物会导致积性损伤. 暴露于更高度导致金属积累增加,氧化应激和炎症,损害功能.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.造成的DNA损伤是DNA损伤.组织病理学 组织病理学炎症 炎症是一种炎症.多重金属 (化物) 混合物氧化应激是一种氧化应激.

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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