在生产中利用纸副产品的机会高性能持续释放基于素的凝
Altaf H Basta1, Vivian F Lotfy1
1Cellulose and Paper Dept., National Research Centre, Dokki 12622, Giza, Egypt.
International journal of biological macromolecules
|August 30, 2024
概括
这项研究优化了将粉碎副产品转化为水凝,以控制酸释放. 接种的炭甲基化黑色液体水凝释放率最高,提供了长时间的药物输送.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 化学工程是化学工程的重要组成部分.
背景情况:
- 粉碎的副产品,如黑色液体 (BL) 是丰富的纤维素废物.
- 来自BL的增值材料的开发对于可持续的工业实践至关重要.
- 水凝为控制药物输送应用提供了潜在的潜力.
研究的目的:
- 为了优化纤维化副产品,以实现有效的水凝合成.
- 开发用于控制释放白酸 (SA) 的水凝.
- 为了研究SA释放动力学和新型水凝的扩散机制.
主要方法:
- 用聚烯胺 (PAM),聚乙醇 (PVA) 和酸盐 (Cs) 制备BL复合水凝.
- BL的碳氧甲基化,然后用烯胺接种.
- 使用ATR-FTIR,TGA,DTG,胀测试,SEM和药物释放研究进行表征.
- 使用Ritger-Peppas和Higuchi模型分析SA释放动力学.
主要成果:
- 接种的碳素甲基化BL凝表现出最大的SA释放 (98.7%).
- 在PAM-BL和PAM/PVA-BL水凝中,SA释放分别为51.7%和43.1%.
- 所有水凝都显示了长时间的SA释放超过48小时.
- SA释放遵循了Fickian和非Fickian扩散途径.
结论:
- 优化制副产品可以产生有效的水凝,用于控制药物输送.
- 接种的碳素甲基化BL-水凝显示出优越的SA释放性能.
- 开发的水凝为酸输送系统提供了一种可持续的方法.
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