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Extraction: Advanced Methods

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...

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Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes

Published on: March 2, 2020

开发一种新的抗菌铜四胺化物抗菌剂.

Veena Wenqing Xu¹, Iris Xiaoxue Yin¹, John Yun Niu¹

¹Faculty of Dentistry, University of Hong Kong, Hong Kong, China.

Journal of dentistry

|August 30, 2024

概括

开发了一种新型的铜四胺化物 (CTF) 溶液,证明了生物相容性和显著的抗菌特性. 这种非变色剂显示为牙科应用的负担得起的抗牙治疗方法.

关键词:

抗菌剂抗菌剂抗菌剂牙损伤导致牙损伤.铜铜铜铜铜铜牙牙是一种牙.化物的化物.

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科学领域:

生物材料科学生物材料科学
牙科研究牙科研究
纳米技术纳米技术

背景情况:

牙损仍然是一个重要的全球健康问题.
目前的治疗方法,如银胺化物 (SDF),可以导致牙变色.
需要有效的,生物相容的,美观的抗菌剂.

研究的目的:

为了合成和描述一种新的铜四胺化物 (CTF) 溶液.
评估CTF的生物相容性,抗菌功效和变色潜力.
为了将CTF与银二胺化物 (SDF) 作为潜在的抗虫剂进行比较.

主要方法:

使用化铜和氨,合成了CTF溶液.
描述包括X射线光电子谱学 (XPS).
细胞毒性评估使用来自人体脱皮叶状牙 (SHED) 和人体牙纤维细胞 (HGF-1) 的干细胞.
使用殖民地形成单元 (CFU) 和共聚焦激光扫描显微镜 (CLSM) 对Streptococcus mutans进行了抗菌活性测试.
用光谱光度测量对牙变色的影响进行了评估.

主要成果:

XPS证实了CTF的合成.
CTF对SHED和HGF-1细胞具有较低的细胞毒性.
CTF对Streptococcus mutans表现出显著的抗菌活性,与SDF相比.
光谱测量显示,与SDF相比,CTF对牙的变色是最小的.
开发的CTF溶液是性 (pH 9),具有高化物度 (121,000 ppm).

结论:

成功开发了一种具有强大的抗菌和不变色特性的生物相容,性CTF溶液.
CTF为预防牙损伤提供了一个有希望的,负担得起的替代SDF.
进一步的临床翻译可以为牙科专业人员在管理中提供一个有价值的工具.