慢性阿莫西西林短缺导致儿科诊所的替代性宽谱抗菌药物使用
Yuto Otsubo1, Nobuaki Matsunaga2, Ai Tsukada2
1Division of Infectious Diseases, Immunology, Department of Pediatrics, Tokyo Metropolitan Children's Medical Center, 2-8-29, Musashidai, Fuchu, Tokyo, 183-8561, Japan; Center for Pediatric Infectious Diseases, Tokyo Metropolitan Children's Medical Center, 2-8-29, Musashidai, Fuchu, Tokyo, 183-8561, Japan.
概括
日本 日本 日本 日本 日本.
科学领域:
- 儿科传染病儿童传染病
- 抗微生物药物管理管理
- 公共卫生政策 公共卫生政策
背景情况:
- 从2023年5月开始,日本经历了阿莫西西林和阿莫西西林 - 克拉夫兰酸的慢性短缺.
- 这种短缺对儿科抗菌素处方模式的影响以前尚不清楚.
研究的目的:
- 分析日本儿科诊所在阿莫西西林短缺之前和之后抗菌素处方趋势的变化.
- 用世卫组织的AWaRe分类来评估所规定的抗微生物药物类别的转变.
主要方法:
- 追溯观察性研究分析了2023年1月至12月的28,888份口服抗菌素处方.
- 数据通过在线监测系统 (OASCIS) 收集.
- 基于AWaRe分类的抗菌素处方率的比较 (三月至五月与六月至八月).
主要成果:
- "访问"抗微生物药物的处方显著下降 (53.9%至46.8%,p < 0.001).
- 对"Watch"抗微生物药物的处方显著增加 (45.9%至52.8%,p < 0.001).
- 在"Watch"类别中,第三代头素的使用率从18.8%上升到24.7% (p < 0.001).
结论:
- 日本的阿莫西西林短缺导致儿科诊所增加了广泛抗微生物药物的使用.
- 这种转变表明对抗微生物药物耐药性模式和管理工作的潜在影响.
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