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球磨加工工艺的机械化学比较,用于levofloxacin无形聚合物系统

Lena Kadri¹, Lucia Casali², Franziska Emmerling³

¹School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, College Green, Dublin 2, Ireland; The Science Foundation Ireland Research Centre for Pharmaceuticals (SSPC), Ireland.

International journal of pharmaceutics

|August 30, 2024

概括

这项研究探讨了使用Eudragit® L100通过球磨法进行levovofloxacin半酸盐 (LVXh) 的无形化. 确定了一种两步形成机制,增强可持续的药物配方方法.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
固态化学固态化学

背景情况:

利沃素半酸盐 (LVXh) 是一种诺基诺类抗生素.
无形化可以提高药物的溶解性和生物可用性.
尤德拉吉特® L100 (EL100) 是药物配方中常用的聚合物辅助剂.

研究的目的:

通过使用Eudragit® L100 (EL100) 来研究勒沃素半酸盐 (LVXh) 的无形化能力.
为了比较不同球磨技术的有效性,以实现LVXh无形化.
阐明LVXh:EL100系统的形成机制和固态特性.

主要方法:

球磨 (BMing) 使用各种型号的磨床.
使用粉末X射线衍射 (PXRD),现场PXRD,差分扫描热度计 (DSC),固态里埃变换红外光谱 (FT-IR) 进行固态特征.
动态蒸汽吸附 (DVS) 分析.

主要成果:

使用EL100的球磨加工实现了LVXh的完全无形化.
确定了系统形成的两步机制 (LVXh无形化接下来是EL100相互作用).
DVS研究显示,LVXh:EL100样本的稳定性根据工厂类型和药物负载而有所不同.

结论:

球磨是一种有效和可持续的方法,用于用EL100无形化LVXh.
了解两步形成机制对于优化药物辅助剂相互作用至关重要.
这项研究有助于制药机械和 tribo 化学药物配方的进步.

关键词:

球磨球磨球磨欧德拉吉特 (Eudragit® L100 L100) 是一种可以使用的材料.在现场监控.利沃弗洛克萨辛 (Levofloxacin) 是一种药物.机械化学机械化学阶段转换阶段转换

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