细胞和分子支青春期皮层厚度与大麻相关的变化
Xavier Navarri1,2, Derek N Robertson2, Iness Charfi2,3
1Department of Neuroscience, Université de Montréal, Montreal, Quebec H3T 1J4, Canada.
概括
青少年使用大麻会通过改变基因表达和神经结构来影响大脑发育. 这项研究将大麻暴露与小鼠和人类皮质厚度和突触功能变化联系在一起.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 青少年大麻实验非常普遍.
- 连接大麻使用与大脑成熟变化的细胞和分子机制尚不清楚.
研究的目的:
- 研究大麻对青少年大脑发育的影响的分子和细胞基础.
- 为了将基因表达变化与青少年大麻使用者的结构性大脑差异相关联.
主要方法:
- 青少年雄性小鼠被暴露在Δ-9-四大麻 (THC) 或WIN 55,212-2 (WIN) 中,评估了基因表达,脊柱数量和树突复杂性.
- 人类青少年 (男性) 根据早期大麻实验 (16岁之前) 进行了分类,并接受了磁共振成像,以评估皮质厚度.
- 来自小鼠的基因表达数据与人类皮质厚度差异的空间相关.
主要成果:
- 在小鼠中,THC和WIN暴露导致基因表达的改变,脊椎损失,以及前皮层中树突复杂性的减少.
- 在人类中,大麻实验与34个大脑区域皮质厚度的变化有关.
- 鼠标识别的DEGs同类体的空间表达与这些皮质厚度差异相关,显示与星球细胞,微质细胞和金字塔细胞的共同表达.
- 基因本体学分析揭示了神经元投影发育 (THC) 和学习/记忆过程 (WIN) 的丰富.
结论:
- 青少年使用大麻可能会通过对谷氨酸突触和树突树木化的影响影响影响皮质厚度.
- 青少年时期的大麻实验可以改变分子通路和细胞结构,这对大脑发育至关重要.
- 这项研究提供了有关早期接触大麻的神经生物学影响的见解.
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