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全身2-[¹⁸F]FDG PET/CT成像的低剂量优化:基于体重指数分层的可行性单中心研究

Taoying Gu^1,2,3,4, Siwei Liu^1,2,3,4, Xiaoguang Hou^1,2,3,4

¹Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, People's Republic of China.

European radiology

|August 30, 2024

概括

根据体重指数 (BMI) 分层的2-[¹⁸F]FDG PET/CT成像的三分之一剂量方案,提供与全剂量方案相比的诊断图像质量和病变检测能力. 这种低剂量方法是个性化核医学方案的可行替代方案.

科学领域:

核医学就是核医学.
放射化学放射化学是指辐射化学.
瘤成像学成像学

背景情况:

个性化医疗需要可适应的低剂量PET/CT协议.
现有的低剂量方案是有限的,特别是对于不同的身体质量指数 (BMI) 患者群体.
优化放射追踪剂量对于患者的安全性和成本效益至关重要.

研究的目的:

评估对2-[¹⁸F]FDG全身PET/CT的三分之一 (1/3) 剂量方案的临床可行性.
评估基于BMI的1/3注射剂量的诊断图像质量和病变检测能力.
为了比较低剂量治疗方案与标准全剂量治疗方案的疗效.

主要方法:

74名癌症患者接受了2-[¹⁸F]FDG全身PET/CT.
37名患者接受了全剂量 (3.7 MBq/kg),37名患者接受了1/3剂量 (1.23 MBq/kg).
1/3剂量组按BMI分层,采用不同的采集时间 (5,6或8分钟),并分析图像质量/损伤检测能力.

主要成果:

主观的图像质量评估显示,1/3剂量和全剂量组之间有很强的读者同意 (κ > 0.88).
客观评估显示,SUVmax,肝脏SUV平均值或TBR在两组之间没有显著差异 (p > 0.05).
损伤检测率相似:93.24%用于1/3剂量,而94.73%用于全剂量 (p = 0.520).

结论:

对2-[¹⁸F]FDG PET/CT进行BMI分层的1/3剂量治疗方案是临床可行的.
这种低剂量方法提供了诊断图像质量和病变检测能力,相当于全剂量方案.
这些发现支持扩大个性化,低剂量PET/CT协议的使用.

关键词:

体重指数 (Body Mass Index) 是一个指数.可行性研究是可行性研究.医学瘤学医学瘤学整体体质子发射断层扫描/计算机断层扫描 [18F]FDGG是什么意思

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