在巴基斯坦的五个浪潮中,住院COVID-19患者的死亡风险因素
Nosheen Nasir1, Salma Tajuddin2, Afshan Akhtar3
1Section of Adult Infectious Diseases, Department of Medicine, Aga Khan University, Karachi, Pakistan. Nosheen.nasir@aku.edu.
Scientific reports
|August 30, 2024
概括
在三角洲波和波后期间,COVID-19死亡风险最高,特别是在老年患者和呼吸道或并发症患者中. 使用埃诺沙巴林的抗凝固药与住院患者的死亡率降低有关.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 关键护理医学 关键护理医学
背景情况:
- 在全球范围内,COVID-19大流行病造成了显著的死亡率.
- 了解不同流行病波的风险因素和结果对于有效管理至关重要.
- 高等保健中心在管理严重的COVID-19病例方面发挥着至关重要的作用.
研究的目的:
- 描述住院COVID-19患者的临床特征和结果.
- 评估不同COVID-19流行浪潮中死亡率的风险因素.
- 评估像埃诺沙巴林这样的干预措施对死亡率的影响.
主要方法:
- 对5368名住院COVID-19患者进行了回顾性队列研究.
- 从2020年3月到2022年4月收集的数据.
- 多变量分析以确定死亡风险因素.
主要成果:
- 总体死亡率为12%.
- 在第4波 (三角洲) 和第4波后期观察到的死亡率最高.
- 关键的死亡风险因素包括ARDS,机械呼吸,AKI,中风,PE和60岁以上的年龄.
- 埃诺沙巴林的使用与死亡率的降低有关.
结论:
- 在各个流行病浪潮中,COVID-19患者的人口统计和结果发生了显著的变化.
- 高龄,ARDS,机械通风,AKI和特定波 (三角形,波后4) 与死亡率的增加有关.
- 用埃诺沙巴林进行抗凝血治疗可能会改善住院COVID-19患者的治疗结果.
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