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在偶发性偏头痛中,视网膜和视神经头部的神经血管变化

Ágnes Patzkó¹, Zoltán Pfund², Adrienne Csutak¹

¹Department of Ophthalmology, University of Pécs Medical School, Rákóczi U. 2, Pécs, 7623, Hungary.

Scientific reports

|August 30, 2024

概括

插曲性偏头痛患者的斑点血管密度降低,视网膜神经纤维层厚度降低. 这些神经血管变化,包括视神经头部的改变,与偏头痛的持续时间和头痛侧面相关,表明微血管损伤.

科学领域:

眼科医生眼科眼科
神经学神经学
医疗成像医学成像

背景情况:

插曲性偏头痛是一种衰弱的神经疾病.
视网膜和视神经头部的神经血管变化可能与偏头痛有关.
了解这些变化可以帮助诊断和管理.

研究的目的:

为了研究情节性偏头痛患者的神经血管变化.
评估黄斑血管密度 (VD),状细胞层 (GCL) 厚度和视神经头部 (ONH) 参数.
为了将这些发现与偏头痛持续时间和头痛横向化相关联.

主要方法:

使用Topcon DRI光连贯断层扫描 (OCT) 和OCT血管造影 (OCTA) 在40名偏头痛患者的80只眼睛上.
将患者的主导偏头痛侧面与健康对照进行比较.
分析了结构和血管参数,包括VD,GCL厚度,RNFL厚度和ONH参数.

主要成果:

与对照组相比,偏头痛患者的表面和深层毛细血管 (SCP,DCP) 的黄斑血管密度 (VD) 显著下降.
在偏头痛患者中扩大了状血管区 (FAZ) 和降低了GCL厚度 (GCL+,GCL++).
观察到视网膜神经纤维层 (RNFL) 厚度减少和视神经头部 (ONH) 边缘组织的Elschnig (BTE) 直径.
偏头痛的持续时间与SCP和DCP血管性相反相关.
主导偏头痛侧显示,与非主导侧相比,VD和GLC++厚度的恶化更大.

结论:

插曲性偏头痛与显著的微血管损伤和视网膜和视神经头部的结构性改变有关.
这些变化与偏头痛持续时间和头痛横向化有关.
OCT和OCTA是检测偏头痛患者这些微妙的神经血管变化的宝贵工具.

关键词:

偏头痛是一种偏头痛.神经血管疾病的发生.视神经的头部视神经的头部光学连贯性断层扫描血管图谱

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