克隆性血液形成与动脉样硬化发展的单向关联
Miriam Díez-Díez1, Beatriz L Ramos-Neble1, Jorge de la Barrera1
1Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
Nature medicine
|August 30, 2024
概括
克隆性造血,即突变干细胞的生长,直接促进动脉样硬化和心血管疾病风险. 这项研究证明了这一点.
科学领域:
- 血液学 血液学 血液学
- 心血管科学 心血管科学
- 遗传学 是一个遗传学.
背景情况:
- 克隆性造血 (CH) 涉及造血干细胞的突变,增加了血液癌症和诸如动脉样硬化等非血液疾病的风险.
- 人们争论CH和动脉样硬化之间的因果关系:CH可能导致动脉样硬化,或者动脉样硬化可能导致CH扩张.
研究的目的:
- 在健康的中年人群中研究克隆造血和动脉样硬化之间的纵向相互作用.
- 为了确定CH是否促进动脉样硬化或反之.
主要方法:
- 血液样本的高灵敏度DNA测序.
- 非侵入性血管成像技术.
- 在健康的中年人群中,经过6年时间的纵向队列研究.
主要成果:
- 具有CH突变的个体在6年内患上新的股骨动脉样硬化风险增加.
- 动脉样硬化的存在或程度在研究期间没有影响突变细胞克隆扩张.
结论:
- 克隆性血液形成单向促进动脉样硬化的发展.
- 研究结果表明,CH是动脉样硬化的一个因果因素,为受影响个体的心血管疾病的预防策略提供信息.
相关概念视频
01:19Multipotency of Hematopoietic Stem Cells
3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K
01:21Hematopoiesis
5.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.2K
01:21Lineage Commitment
3.0K
Commitment is the process whereby stem cells:
3.0K
01:38Inflammation
53.2K
Overview
53.2K
01:01Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
01:34Production of Formed Elements
1.3K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Most HSCs commit to...
1.3K