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血清甲状腺激素和甲状腺激素水平与糖尿病病的相关性:一个横截面研究

Jie Gao¹, Jingfang Liu^2,3

¹The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.

BMC endocrine disorders

|August 30, 2024

概括

升高的TSH和降低的FT3水平与2型糖尿病患者的糖尿病病 (DKD) 有关. 自由三甲状腺素 (FT3) 对DKD的预测值比TSH更强.

科学领域:

内分泌学在内分泌学.
腎臟病學 (nephrology) 是一種醫學專業.
代谢障碍代谢障碍代谢障碍

背景情况:

糖尿病病 (DKD) 是2型糖尿病 (T2DM) 的一个主要并发症.
甲状腺功能障碍和DKD之间的关联仍然存在争议.
甲状腺激素,包括甲状腺激素 (TSH),自由三甲状腺素 (FT3) 和自由甲状腺素 (FT4),在代谢调节中起着至关重要的作用.

研究的目的:

在T2DM患者中调查TSH,FT3,FT4和DKD之间的相关性.
确定TSH和FT3对DKD发展的预测价值.

主要方法:

一组1216名T2DM患者根据血清TSH,FT3和FT4水平被分为五组.
测量了尿中白蛋白分泌率 (UACR) 和估计的淋巴膜过率 (eGFR).
使用二进制物流回归和ROC曲线分析来评估相关性和预测值.

主要成果:

患有甲状腺功能低下症的患者表现出较高的白蛋白尿和降低的EGFR.
TSH与UACR正相关,与eGFR负相关,而FT3显示逆相关性.
经过调整后的分析证实了TSH和FT3是增加UACR和降低eGFR的独立预测因子,FT3显示出更高的预测值 (AUC为0.64对比TSH的0.61).

结论:

增加的TSH和减少的FT3水平与T2DM患者的DKD显著相关.
在男性中没有观察到TSH和eGFR<60mL/min/1.73m2之间的关联.
与TSH相比,FT3对DKD具有更强的预测能力.

关键词:

糖尿病脏疾病糖尿病脏疾病甲状腺功能低下症甲状腺功能低下症甲状腺荷尔蒙是什么?甲状腺荷尔蒙是什么?甲状腺增生蛋白 (Thyrotropin) 是一种甲状腺增生蛋白.

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